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Abstract #1435

T1 and T2 Mapping of Delayed Gadolinium Enhancement in Osteoarthritis with MR Fingerprinting

Joshua D Kaggie1,2, James MacKay1,2, Guido Buonincontri3, Fiona J Gilbert1,2, Rolf F Schulte4, Alexandra R Morgan5, Robert L Janiczek5, Michela Tosetti3, Andrew McCaskie2,6, and Martin J Graves1,2

1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 3IRCCS Stella Maris and IMAGO7 Foundation, Pisa, United Kingdom, 4GE Healthcare, Munich, Germany, 5Experimental Medicine Imaging, GlaxoSmithKline, London, United Kingdom, 6Division of Trauma and Orthopaedic Surgery, University of Cambridge, Cambridge, United Kingdom

Mapping of quantitative MRI relaxation values is promising for improving the assessment of MSK disease. Magnetic Resonance Fingerprinting (MRF) is a new method that enables fast quantitative MRI by exploiting the transient signals caused by the variation of pseudorandom sequence parameters.

This proof-of-concept work demonstrates the utility of MR Fingerprinting in the knee. Seven participants, four of which had Kellgren-Lawrence (KL) grade 2 or 3, were imaged eighty minutes after gadolinium injection with MRF on a 3.0T MRI. The mean T1 relaxation times were shorter in cartilage by 5-20% in KL=2,3 subjects when compared to normal subjects.

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