Abstract #1436

Significant Metabolic Differences Between Benign Lipomatous Lesion and Liposarcoma Identified by High-Resolution 1H and 31P MRS: A Pilot Study

Santosh Kumar Bharti¹, Brett Shannon², Adam Levin², Carol D Morris², Laura Fayad³, and Zaver M Bhujwalla^1,4

¹Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ²Department of Orthopaedic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ³Musculoskeletal Radiology, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ⁴Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Adipocytic tumors present a spectrum of neoplastic disease including benign lipomas and their variants, atypical lipomatous tumors, and malignant liposarcomas. Distinguishing areas of malignant dedifferentiation from benign and atypical lipomatous tumors is a diagnostic challenge due to overlapping magnetic resonance imaging characteristics, and pre-operative diagnostic accuracy is poor. Here we have identified dramatic differences in the metabolic profile of water-soluble and lipid extracts of adipocytic tumors, suggesting that magnetic resonsance spectroscopy may have the potential to improve diagnostic accuracy. Our data may also lead to potential metabolic targets for treatment.

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