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Abstract #1443

Chemical Shift Quantitative Magnetic Susceptibility Study of Ex-vivo Human Cortical Bone Specimen with three-dimensional ConesĀ ultra-short echo time (UTE) imaging

Xing Lu1,2, Saeed Jerban1, Michael Carl3, Yajun Ma1, Annette von Drygalski4, Eric Y Chang5, and Jiang Du1

1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Institute of Electrical Engineering, Chinese Academy of Science, Beijing, China, 3GE Healthcare, San Diego, CA, United States, 4Department of Medicine, Division of Hematology/Oncology, University of California, San Diego, San Diego, CA, United States, 5Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Bone mineral density (BMD) evaluation is crucial for the diagnosis of osteoporosis and related fractures. The purpose of this pilot study was to use a chemical-shift QSM method based on a 3D UTE-Cones sequence to assess the susceptibility values of human cortical bone specimens with consideration of gender and donor age, ranging over 5 decades. Significant differences between QSM values were observed for the different genders. A decaying trend between the minus QSM value and advancing age exists, which suggests a relationship between QSM values and BMD.

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