Abstract #1443

Chemical Shift Quantitative Magnetic Susceptibility Study of Ex-vivo Human Cortical Bone Specimen with three-dimensional Cones ultra-short echo time (UTE) imaging

Xing Lu^1,2, Saeed Jerban¹, Michael Carl³, Yajun Ma¹, Annette von Drygalski⁴, Eric Y Chang⁵, and Jiang Du¹

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Institute of Electrical Engineering, Chinese Academy of Science, Beijing, China, ³GE Healthcare, San Diego, CA, United States, ⁴Department of Medicine, Division of Hematology/Oncology, University of California, San Diego, San Diego, CA, United States, ⁵Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Bone mineral density (BMD) evaluation is crucial for the diagnosis of osteoporosis and related fractures. The purpose of this pilot study was to use a chemical-shift QSM method based on a 3D UTE-Cones sequence to assess the susceptibility values of human cortical bone specimens with consideration of gender and donor age, ranging over 5 decades. Significant differences between QSM values were observed for the different genders. A decaying trend between the minus QSM value and advancing age exists, which suggests a relationship between QSM values and BMD.

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