This study aimed to evaluate the diagnostic performance of diffusion weighted imaging (DWI) to differentiate metastasis from myeloma using the apparent diffusion coefficient (ADC) and parameters derived from the intravoxel incoherent motion (IVIM) theory. 40 patients with metastasis and 12 with myeloma underwent diffusion-weighted magnetic resonance (MR) imaging and dynamic contrast enhanced MRI (DCE-MRI). ADC, diffusion coefficient(D), pseudodiffusion coefficient(D*), and perfusion fraction (f) were calculated.Through our study it is feasible to d ifferentiate metastasis from myeloma by mono-exponential and IVIM models . IVIM-derived D and D* values showed significantly better diagnostic performance than ADC values in differentiating metastasis from myeloma.
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