Abstract #1475

Development and evaluation of a single-phase alloy with magnetic susceptibility equivalent to that of mammalian tissue for coil embolization of a cerebral aneurysm

Ryusuke Nakai^1,2, Takashi Azuma³, Mitsuaki Toda², Tomonobu Kodata⁴, and Hiroo Iwata²

¹Kokoro Research Center, Kyoto University, Kyoto, Japan, ²Institute for Frontier and Medical Life Sciences, Kyoto University, Kyoto, Japan, ³Graduate School of Engineering, Kyoto University, Kyoto, Japan, ⁴Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan

Relatively less invasive MRI has recently been increasingly used for examination after coil embolization of a cerebral aneurysm, but there is a risk of misdiagnosis due to magnetic susceptibility artifacts. In this study, we developed a device composed of a highly biocompatible alloy with magnetic susceptibility equivalent to that of mammalian tissue, and evaluated it using both an in vitro model and rabbits. We found that this alloy markedly reduced magnetic susceptibility artifacts and can be used as a device in the body. We are planning to develop various implantable medical devices using this alloy.

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