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Abstract #1476

Evaluation of 2D simultaneous multi-slice EPI for high resolution thermometry in the brain at 3T.

Valéry Ozenne1,2,3, Pierre Bour1,2,3,4, Mathieu Santin5,6, Romain Valabrègue5,6, Charlotte Constans7, Aurélien Trotier8, Sylvain Miraux8, Jean-Francois Aubry7, and Bruno Quesson1,2,3

1IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, Bordeaux, France, 2Univ. Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, 3INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France, 4Image Guided Therapy SA, Bordeaux, France, 5CENIR, Centre de NeuroImagerie de Recherche, Paris, France, 6ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France, 7Institut Langevin Ondes et Images, ESPCI ParisTech, CNRS 7587, UMRS 979 INSERM, Paris, France, 8Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536, CNRS, Univ. Bordeaux, Bordeaux, France

MR-guided HIFU in the brain currently lacks from insufficient spatial and temporal monitoring of the effect of ultrasound. In this study, we combine simultaneous multi-slice (SMS) echo planar imaging (EPI) technique with in-plane parallel imaging to achieve high spatial resolution with large volume coverage and/or short acquisition time during temperature mapping at 3T. The sequence was tested in vivo in a human brain with different multiband (MB) factors. SMS reconstruction and temperature mapping were computed using the Gadgetron framework. Then, validation was performed on an ex vivo chicken muscle during HIFU sonication to validate the method.

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