Abstract #1484

Development of a Tissue Mimicking Phantom for Focal Laser Ablation of the Prostate

Rory Geoghegan^1,2, Alan Priester^2,3, Alvaro Santamaria³, Le Zhang⁴, Samantha Mikaiel⁴, Holden Wu⁴, Warren Grundfest^1,2, Leonard Marks³, and Shyam Natarajan^1,2,3

¹Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ²Center for Advanced Surgical & Interventional Technology, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Urology, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Radiology, University of California, Los Angeles, Los Angeles, CA, United States

There is a need to further develop real-time feedback systems for monitoring focal laser ablation (FLA). Here we have developed a tissue mimicking phantom to facilitate research on the use of magnetic resonance thermometry (MRT) and interstitial thermal probes as feedback systems. The tissue mimicking phantom was designed to match the optical and thermal properties of prostatic tissue at 980nm. The thermal response of the phantom to FLA was then compared to previously acquired clinical data and found to be qualitatively and quantitively similar to prostatic tissue. MRT and real-time quantification of damage zone progression are also demonstrated.

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