Abstract #1490

Detection of Acoustic Radiation Force-Induced Aggregated Bubbles by Velocity and Vorticity Maps

Che-Wei Wu¹, Po-Hung Hsu², Hao-Li Liu³, Chen-Hua Wu¹, Ching-Hsiang Fan¹, Chih-Kuang Yeh¹, Wen-Shiang Chen^4,5, and Hsu-Hsia Peng¹

¹Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³Electrical Engineering, Chang-gung University, Taoyuan, Taiwan, ⁴Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, ⁵Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

The aim of this study was to real-time localize the occurrence of secondary ARF and the aggregated bubbles by velocity and vorticity maps. During FUS transmission, the flow velocity and vorticity downstream to the FUS focus increased substantially. By observing the pixel-wise flow behavior in a scatter plot with information of velocity and vorticity, the position of aggregated bubbles could be localized in the regions with decreased velocity and vorticity. In conclusion, we verified the feasibility of using phase-contrast MRI to real-time detect secondary ARF and aggregated bubbles by combining pixel-wise velocity and vorticity information.

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