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Abstract #1490

Detection of Acoustic Radiation Force-Induced Aggregated Bubbles by Velocity and Vorticity Maps

Che-Wei Wu1, Po-Hung Hsu2, Hao-Li Liu3, Chen-Hua Wu1, Ching-Hsiang Fan1, Chih-Kuang Yeh1, Wen-Shiang Chen4,5, and Hsu-Hsia Peng1

1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 3Electrical Engineering, Chang-gung University, Taoyuan, Taiwan, 4Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, 5Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

The aim of this study was to real-time localize the occurrence of secondary ARF and the aggregated bubbles by velocity and vorticity maps. During FUS transmission, the flow velocity and vorticity downstream to the FUS focus increased substantially. By observing the pixel-wise flow behavior in a scatter plot with information of velocity and vorticity, the position of aggregated bubbles could be localized in the regions with decreased velocity and vorticity. In conclusion, we verified the feasibility of using phase-contrast MRI to real-time detect secondary ARF and aggregated bubbles by combining pixel-wise velocity and vorticity information.

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