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Abstract #1491

Evaluate Acoustic Radiation Force Induced Displacement of High Velocity Core by Phase-contrast MRI

Che-Wei Wu1, Po-Hung Hsu2, Hao-Li Liu3, Chen-Hua Wu1, Ching-Hsiang Fan1, Chih-Kuang Yeh1, Wen-Shiang Chen4,5, and Hsu-Hsia Peng1

1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 3Electrical Engineering, Chang-gung University, Taoyuan, Taiwan, 4Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, 5Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

We hypothesized that the aggregated bubbles could be seen as a barrier, which might alter the flow pattern by shifting the high velocity core of flowing fluid. The aim was to assess the secondary acoustic radiation force and the size of aggregated bubbles, and thereby to estimate the amount of delivered drug in the targeting tissue. We found that larger displacement generally occurred with higher acoustic pressure, higher microbubble concentration, and slower flow velocity. In conclusion, we verified the feasibility of using phase-contrast MRI to evaluate the displacement of high velocity core in a phantom with flow microbubbles.

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