Abstract #1491

Evaluate Acoustic Radiation Force Induced Displacement of High Velocity Core by Phase-contrast MRI

Che-Wei Wu¹, Po-Hung Hsu², Hao-Li Liu³, Chen-Hua Wu¹, Ching-Hsiang Fan¹, Chih-Kuang Yeh¹, Wen-Shiang Chen^4,5, and Hsu-Hsia Peng¹

¹Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³Electrical Engineering, Chang-gung University, Taoyuan, Taiwan, ⁴Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, ⁵Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

We hypothesized that the aggregated bubbles could be seen as a barrier, which might alter the flow pattern by shifting the high velocity core of flowing fluid. The aim was to assess the secondary acoustic radiation force and the size of aggregated bubbles, and thereby to estimate the amount of delivered drug in the targeting tissue. We found that larger displacement generally occurred with higher acoustic pressure, higher microbubble concentration, and slower flow velocity. In conclusion, we verified the feasibility of using phase-contrast MRI to evaluate the displacement of high velocity core in a phantom with flow microbubbles.

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