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Abstract #1495

Detecting T1-based signal reduction in focused ultrasound heating of bone at 1.5T using a 3D spiral ultra-short echo time sequence

Helen Sporkin1, Yekaterina K Gilbo1, Sam W Fielden2, John P Mugler3, G. Wilson Miller3, Josef Pfeuffer4, Berthold Kiefer4, and Craig H Meyer1,3

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA, United States, 3Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 4Application Development, Siemens Healthcare, Erlangen, Germany

MR-guided Focused Ultrasound (MRgFUS) is used transcranially to ablate brain tissue for the treatment of essential tremor and Parkinson's disease symptoms. Proton resonance frequency shift MR thermometry detects changes in temperature in tissues with sufficiently long T2, but fails to detect heating in the cortical bone of the skull. T1-based MR thermometry uses T1 mapping to observe a linear increase in T1 with temperature but requires long acquisitions. We demonstrate a thermometry method using the linear relationship between signal magnitude from a T1-weighted 3D Spiral Ultra-short Echo Time sequence and temperature in focused ultrasound heated bone with improved temporal resolution.

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