Preclinical studies using animal disease models on clinical MR-HIFU systems are important for human clinical translations but are often very challenging. We developed and tested a set of hardware components to treat a transgenic mouse model of pancreatic ductal adenocarcinoma on our clinical MR-HIFU system. The hardware components include an optimized RF coil, filter, RF switches and coil/animal holder. A gel phantom and a fixed mouse body were sonicated using the developed devices and a mild hyperthermia protocol on a 3T MR-HIFU system. Pulse sequences for multi-parametric MRI were also tested to acquire optimum signal-to-noise ratio on the samples.