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Abstract #1515

Adult eye segmentation in MRI using active shape model: towards a personalized eye model for radiation treatment of uveal melanoma

Huu-Giao Nguyen, PhD1,2,3, Raphael Sznitman, Prof. 2, Marta Peroni, PhD1, Jan Hrbacek, PhD1, Damien C. Weber, Prof. MD1, Alessia Pica, MD1, and Meritxell Bach Cuadra, PhD3,4

1Proton therapy Center, Paul Scherrer Institut (PSI), ETH Domain, Villigen, Switzerland, 2Ophthalmic Technology Laboratory, ARTORG Center of the University of Bern, Bern, Switzerland, 3Radiology Department, Centre d’Imagerie BioMédicale, Lausanne University Hospital, Lausanne, Switzerland, 4Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

We aim to construct a 3-dimensional patient-specific eye model from MRI data in order to later be integrated into proton radiation treatment planning. Our major challenge is the presence of motion, as subjects are awake and physiologically blink eyes. Additionally, fixing a point during acquisition might be challenging for some patients with ocular tumors. As such, in this study we evaluated an Active Shape Model (ASM) segmentation on a data set of 31 subjects, including 3 uveal melanoma (UM) patients. Quantitative evaluation in comparison with manual delineations shows good accuracy, even for images with the presence of UM and tantalum clips.

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