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Abstract #1514

DKI can early detect radio-insensitive human nasopharyngeal carcinoma xenograft in nude mice

Xiang Zheng1, Yunbin Chen1, Youping Xiao1, and Dechun Zheng1

1Fujian Provincial Cancer Hospital, Fuzhou, China

In order to evaluate feasibility of DKI sequence in early differentiating radio-insensitivity of nasopharyngeal carcinoma xenografts, Seventy-two nude mice were implanted with CNE-1(low radiosensitivity) and CNE-2(high radiosensitivity) and the xenografts were obtained. MRI scanning was performed after fractional irradiation. There are differences of the changes of DKI parameters (both D and K) between CNE-1 and CNE-2 before tumor volumes changed. Therefore, Both D and K can early (before volumes changed) distinguish radio-insensitive NPC xenografts from others.

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