DKI can early detect radio-insensitive human nasopharyngeal carcinoma xenograft in nude mice

In order to evaluate feasibility of DKI sequence in early differentiating radio-insensitivity of nasopharyngeal carcinoma xenografts, Seventy-two nude mice were implanted with CNE-1(low radiosensitivity) and CNE-2(high radiosensitivity) and the xenografts were obtained. MRI scanning was performed after fractional irradiation. There are differences of the changes of DKI parameters (both D and K) between CNE-1 and CNE-2 before tumor volumes changed. Therefore, Both D and K can early (before volumes changed) distinguish radio-insensitive NPC xenografts from others.