There is great, unmet need in understanding and monitoring non-invasively the immune cell changes within the tumour stromal microenvironment during cancer treatment. However there is as yet no reliable non-invasive method of identifying at very early time points patients who are most likely to benefit from this relatively expensive class of treatments which generally are only associated with a clinical response in 25-30% of patients1. We show here in a mouse model that changes 11 days after implantation in the liquid-to-solid ratio (phase angle y) of the tumour biomechanics are indicative for successful immune cell – stromal cell interactions.
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