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Abstract #1513

Exploring the use of MR Elastography to probe immune cell-stromal interaction in tumour microenvironment

Ralph Sinkus1, Rachel Evans2, Fabian Flores-Borja3, and Tony Ng2

1Department of Radiological Imaging, King's College London, London, United Kingdom, 2School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom, 3School of Cancer and Pharmaceutical Sciences King's College London, London, United Kingdom

There is great, unmet need in understanding and monitoring non-invasively the immune cell changes within the tumour stromal microenvironment during cancer treatment. However there is as yet no reliable non-invasive method of identifying at very early time points patients who are most likely to benefit from this relatively expensive class of treatments which generally are only associated with a clinical response in 25-30% of patients1. We show here in a mouse model that changes 11 days after implantation in the liquid-to-solid ratio (phase angle y) of the tumour biomechanics are indicative for successful immune cell – stromal cell interactions.

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