Whole tumor ADC histogram parameters were assessed as early response biomarkers to platinum-based neo-adjuvant chemotherapy in 14 patients with non small cell lung cancer. On completion of treatment, 3 of 11 patients with DW-MRI at baseline and day 14 were classed responders by RECIST criteria. At Day 14 of treatment, there was a significant reduction in ADC metrics in responders (2 of 3 beyond limits of agreement) compared to non-responders (2 of 11 beyond limits of agreement). An increase in ADC 75th centile (indicating more voxels with higher ADC values), was consistent with necrosis; non-responders did not show this change.
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