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Abstract #1527

Assessment of micronecrotic tumor tissue using dynamic contrast-enhanced magnetic resonance imaging

Olga Schimpf1, Stefan Hindel1, and Lutz L├╝demann1

1Strahlenklinik, Med. Physik, Universit├Ątsklinikum Essen, Essen, Germany

Compartmental models for evaluation of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) datasets assume a homogeneous interstitital volume distribution and homogeneous contrast agent (CA) distribution within each compartment, neglecting effects of CA diffusion within the compartments. When necrotic or micronecrotic tumor tissue is present, these assumptions may no longer be valid. Therefore, the present study investigates the validity of three compartmental models in assessing tumors with necrotic components.

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