Abstract #1526

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging

Kate Moodie¹, Nick Ferris², David Thomas³, Mandy Ballinger³, Emma Galligan¹, Marion Harris⁴, Paul James¹, Gillian Mitchell¹, Eveline Niedermayr¹, Bimal Parameswaran⁵, Deborah Schofield³, Sue Shanley⁶, Alison Trainer¹, and Mary-Anne Young¹

¹Peter MacCallum Cancer Centre, Melbourne, Australia, ²Monash Imaging, Monash Health, Melbourne, Australia, ³Garvan Institute of Medical Research, Sydney, Australia, ⁴Monash Health, Melbourne, Australia, ⁵Eastern Health, Melbourne, Australia, ⁶Peter MacCallum Cancer Institute, Melbourne, Australia

Germline TP53 mutations are associated with Li-Fraumeni syndrome (LFS). Mutation carriers ascertained on family history have an extremely high lifetime risk of cancers arising from one or more of many possible sites. There is no established screening strategy for early detection and treatment of these cancers. Herein, we report preliminary data from a prospective study of a whole-body screening program that includes whole-body. Five new malignancies (3 de novo, 2 recurrent) have been identified in five of the first 30 participants, suggesting potentially significant benefits from screening in this population.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.