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Abstract #1536

Functional MRI at ultra-high field strength (11.7 T) for evaluation of rectal cancer stromal heterogeneity ex vivo: correlation with histopathology

Trang Thanh Pham1,2,3,4,5, Timothy Stait-Gardner6, C. Soon Lee3,4,5,7, Michael B. Barton 1,3,4, Gary Liney1,3,4, Karen Wong1,3,4, and William S. Price5,6

1Radiation Oncology, Liverpool Cancer Therapy Centre, Liverpool Hospital, Sydney, Australia, 2Sydney West Radiation Oncology Network, Westmead, Blacktown and Nepean Hospitals, Sydney, Australia, 3Faculty of Medicine, University of New South Wales, Sydney, Australia, 4Ingham Institute for Applied Medical Research, Sydney, Australia, 5School of Medicine, Western Sydney University, Sydney, Australia, 6Nanoscale Organisation and Dynamics Group, Western Sydney University and National Imaging Facility, Sydney, Australia, 7Anatomical Pathology, Liverpool Hospital, Sydney, Australia

Diffusion Tensor Imaging (DTI) MRI at ultra-high field (11.7 T) was used to examine the stromal ultrastructure of malignant and normal rectal tissue ex vivo, and findings were correlated with histopathology. DTI was able to distinguish tumour from desmoplasia: tumour was found to have isotropic diffusion, whereas desmoplastic reaction or fibrous tissue had moderately anisotropic diffusion. DTI was useful in assessing depth of tumour infiltration into rectal wall: tumour was able to be distinguished from muscularis propria which was highly organised and anisotropic. This study showed that DTI-MRI can assist in more accurately defining tumour extent in rectal cancer.

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