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Abstract #1537

Assessment of treatment response of lymphoma in an animal model with in vivo MR elastography

Jing Guo1, Animesh Bhattacharya2, Gergely Bertalan1, Jürgen Braun3, Clemens A. Schmitt2,4,5, and Ingolf Sack1

1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Medica Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center (MKFZ), Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Berlin Institute of Health (BIH), Berlin, Germany, 5Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany

In this feasibility study, we have characterized the mechanical properties of lymphoma directly in the cervical lymph nodes with in vivo multifrequency MRE for the first time. Both MRE and diffusion weighted imaging were used to investigate the tumor's response to chemotherapy. We found that lymphomas stiffened 24 hours after chemotherapy which was accompanied by increased apparent diffusion coefficient (ADC) and reduced tumor volume. Wave speed obtained from MRE is sensitive in detecting the mechanical response of lymphoma to chemotherapy. Observed tumor stiffening post treatment needs to be validated by larger group size and should be explained by histological analysis.

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