Abstract #1537

Assessment of treatment response of lymphoma in an animal model with in vivo MR elastography

Jing Guo¹, Animesh Bhattacharya², Gergely Bertalan¹, Jürgen Braun³, Clemens A. Schmitt^2,4,5, and Ingolf Sack¹

¹Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Medica Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center (MKFZ), Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Berlin Institute of Health (BIH), Berlin, Germany, ⁵Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany

In this feasibility study, we have characterized the mechanical properties of lymphoma directly in the cervical lymph nodes with in vivo multifrequency MRE for the first time. Both MRE and diffusion weighted imaging were used to investigate the tumor's response to chemotherapy. We found that lymphomas stiffened 24 hours after chemotherapy which was accompanied by increased apparent diffusion coefficient (ADC) and reduced tumor volume. Wave speed obtained from MRE is sensitive in detecting the mechanical response of lymphoma to chemotherapy. Observed tumor stiffening post treatment needs to be validated by larger group size and should be explained by histological analysis.

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