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Abstract #1540

MP2RAGE-Compressed Sensing for fast metastasis detection and characterization in mice

Aurélien Trotier1, Stanislas Rapacchi2, Thibaut Faller1, Sylvain Miraux1, and Emeline Ribot1

1CRMSB UMR5536, CNRS-Univ.Bordeaux, Bordeaux, France, 2CRMBM UMR7339, CNRS/Aix-Marseille Univ., Marseille, France

In order to detect and characterize metastases in preclinical studies, 3D T1 maps can be obtained with the MP2RAGE sequence. As high spatial resolution is required, the acquisition duration becomes prohibitive for the monitoring of metastases. Thus, acceleration via Compressed Sensing technique was achieved, necessitating a new undersampling scheme. T1 maps of the mouse whole brain were obtained in <1min. The T1 of brain metastases was not affected by CS acceleration. Then, ultra-high spatially resolved maps (130x125x141μm) were acquired without lengthening scan time, to detect early-growing metastases and accurately measure their volumes.

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