Abstract #1542

MRI exploration of the subventricular region of the third ventricle and its association with neurofibromatosis type-1 and white matter integrity in children with optic pathway glioma

Natalie R Boonzaier¹, Patrick W Hales¹, Felice D’Arco², Kshitij Mankad², Darren Hargrave³, and Christopher Clark¹

¹Developmental Imaging and Biophysics Section, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, United Kingdom, ²Radiology Department, Great Ormond Street Children's Hospital, London, United Kingdom, ³Haematology and Oncology Department, Great Ormond Street Children's Hospital, London, United Kingdom

The lateral subventricular zone has been explored in association with high-grade gliomas, both in-vivo and with MRI. The third ventricle subventricular zone (TVZ) has been explored in-vivo, using immunohistochemistry and microarray analysis, with regard to neurofibromatosis type-1-associated low-grade optic pathway gliomas. This remains unexplored with MRI. This study examined diffusion MRI features of the TVZ and its association with NF1-status and peri-tumour white matter integrity. TVZ features correlated with NF1-status, and peri-tumour white matter integrity. These results suggest that the state of the TVZ environment can potentially indicate whether a sporadic tumour might behave like its less disruptive NF1-associated counterpart.

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