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Abstract #1551

Integrating Magnetic Resonance Imaging with Live Lung Intravital Microscopy: A Novel Platform to Evaluate the Effect of Radiation on Lung Tumors

Shampa Chatterjee1, Luis Loza2, Mehrdad Pourfathi2, Sarmad Siddiqui2, Jian Tao1, Harrilla Profka2, Ian Duncan2, Hooman Hamedani2, Kai Ruppert2, Diane Lim3, Yan Liu3, Jose Conejo-Garcia4, Mary Spencer2, Tahmina Achekzai2, Stephen Kadlecek2, and Rahim R. Rizi2

1Physiology, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Sleep Medicine, University of Pennsylvania, Philadelphia, PA, United States, 4Moffitt Cancer Center, Tampa, FL, United States

We propose that, when used in combination with MRI imaging, live lung intravital fluorescence microscopy can be a powerful tool for detecting the effects of radiotherapy on lung tumors. In this study, we monitored pulmonary nodules pre- and post-radiation in a novel murine model (Kras(G12D)/p53fl/fl/myr-p110) with tumor regulation by Cre-recombinase. Using the reporter gene EGFP fluorescence, a significant loss of the tumor was observed post-radiation, which correlated with reduced fluorescent signal from the same region of the lung.

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