Abstract #1552

Effect of Stereotactic Body Radiotherapy on Perfusion and Diffusion in Prostate Tumor and Benign Tissue

Kristen Zakian¹, Hebert Vargas Alvarez^1,2, Andreas Wibmer², Aditi Iyer², Neelam Tyagi², Aditya Apte², Marissa Kollmeier², Boris Mychalczak², Karen Borofsky², Oren Cahlon², Yousef Mazaheri Tehrani², Margie Hunt², and Michael Zelefsky²

¹Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²1275 York Avenue, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Multimodality MRI including DCE-MRI and DW-MRI were performed in patients prior to and following hypofractionated stereotactic body radiotherapy (SBRT). Diffusion and perfusion related parameters in both tumor and non-tumor benign tissue were calculated at 3, 6, and 12 months after SBRT. Radiation-induced changes were observed in perfusion and diffusion related parameters in tumors. In the non-tumor transition zone, SBRT induced changes in perfusion-related parameters. Multimodality MRI has potential for treatment effect monitoring in the prostate after SBRT.

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