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Abstract #1552

Effect of Stereotactic Body Radiotherapy on Perfusion and Diffusion in Prostate Tumor and Benign Tissue

Kristen Zakian1, Hebert Vargas Alvarez1,2, Andreas Wibmer2, Aditi Iyer2, Neelam Tyagi2, Aditya Apte2, Marissa Kollmeier2, Boris Mychalczak2, Karen Borofsky2, Oren Cahlon2, Yousef Mazaheri Tehrani2, Margie Hunt2, and Michael Zelefsky2

1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 21275 York Avenue, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Multimodality MRI including DCE-MRI and DW-MRI were performed in patients prior to and following hypofractionated stereotactic body radiotherapy (SBRT). Diffusion and perfusion related parameters in both tumor and non-tumor benign tissue were calculated at 3, 6, and 12 months after SBRT. Radiation-induced changes were observed in perfusion and diffusion related parameters in tumors. In the non-tumor transition zone, SBRT induced changes in perfusion-related parameters. Multimodality MRI has potential for treatment effect monitoring in the prostate after SBRT.

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