FLAIR MR images feature striking contrast, allowing easy identification of white matter hyperintense lesions. While such lesions have been explained by a range of microstructural characteristics, FLAIR itself doesn't provide specificity to distinguish these heterogeneous origins. 3-tissue CSD techniques resolve white matter (WM), grey matter (GM) and CSF compartments. In lesions, GM-like and CSF-like diffusion-weighted signals have been hypothesised to be related to certain origins, e.g. gliosis or increased interstitial fluid. We propose a fusion of 3-tissue encoded colours and FLAIR via panchromatic sharpening techniques, designed for improved characterisation of white matter lesion heterogeneity.
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