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Abstract #1570

Tissue-Encoded Colour Fluid-Attenuated Inversion Recovery (TEC-FLAIR) map: contrast fusion designed for improved characterisation of white matter lesion heterogeneity

Thijs Dhollander1, Remika Mito1,2, and Alan Connelly1,2

1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2The Florey Department of Neuroscience, University of Melbourne, Melbourne, Australia

FLAIR MR images feature striking contrast, allowing easy identification of white matter hyperintense lesions. While such lesions have been explained by a range of microstructural characteristics, FLAIR itself doesn't provide specificity to distinguish these heterogeneous origins. 3-tissue CSD techniques resolve white matter (WM), grey matter (GM) and CSF compartments. In lesions, GM-like and CSF-like diffusion-weighted signals have been hypothesised to be related to certain origins, e.g. gliosis or increased interstitial fluid. We propose a fusion of 3-tissue encoded colours and FLAIR via panchromatic sharpening techniques, designed for improved characterisation of white matter lesion heterogeneity.

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