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Abstract #1571

Linking neurocognitive measures with whole brain structure using Diffusion ODFs in the HCP dataset

Steven H. Baete1,2, Ying-Chia Lin1,2, Jingyun Chen1,2,3, Ricardo Otazo1,2, and Fernando E. Boada1,2

1Center for Advanced Imaging Innovation and Research (CAIR), NYU School Of Medicine, New York, NY, United States, 2Center for Biomedical Imaging, Dept of Radiology, NYU School Of Medicine, New York, NY, United States, 3Dept of Psychiatry, NYU School Of Medicine, New York, NY, United States

Higher dimensional diffusion protocols are now routinely acquired in large-scale studies. While these diffusion data sets contain a wealth of information about white matter architecture, this information is not fully exploited when their dimensionality is reduced to simplify statistical correlations with neurocognitive markers over the whole brain. To overcome this limitation, we analyze the full Orientation Distribution Function (ODF) at each voxel using a Low-Rank plus Sparse decomposition to identify key ODF features. We use this approach to link neurocognitive measures to brain structure in a cohort of healthy Human Connectome Project volunteers.

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