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Abstract #1577

Anatomical atlas of MAP MRI-derived 3D diffusion propagators and microstructural parameters

Alexandru V Avram1, Adam S Bernstein2, M. Okan Irfanoglu1, Amber Simmons2, Martin Cota3, Neville Gai4, Neekita Jikaria3, Anita Moses3, Christine L Turtzo3, Lawrence Latour3, Dzung Pham4, John A Butman4, and Peter J Basser5

1NIBIB, National Institutes of Health, Bethesda, MD, United States, 2NICHD, National Institutes of Health, Bethesda, MD, United States, 3NINDS, National Institutes of Health, Bethesda, MD, United States, 4Diagnostic Radiology, National Institutes of Health, Bethesda, MD, United States, 5National Institutes of Health, Bethesda, MD, United States

We describe the construction of an anatomical template of 3D probability distributions water molecule displacements in tissues (i.e., diffusion propagators) measured with MAP MRI in a population of healthy volunteers. From the template of 3D diffusion propagators, we compute normative values of MAP MRI microstructural parameters and visualize the orientational characteristics of water net displacement profiles using orientation distribution functions (ODFs). This atlas could provide a reference for protocol development in longitudinal and multi-center studies, and for clinical studies seeking to detect and characterize subtle microstructural changes, such as those occurring in mild traumatic brain injury (mTBI), or metastatic cancer.

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Abstract