Abstract #1578

Spatial normalization of individual fractional anisotropy (FA) maps to widely used population templates for analysis can increase variability and create spurious differences in the measured FA values

Amritha Nayak^1,2, Elisabeth Wilde³, Brian Taylor³, CENC Neuroimaging Core Investigators⁴, Laura Reyes^1,2, and Carlo Pierpaoli¹

¹Quantitative Medical Imaging Section, NIBIB, NIH, Bethesda, MD, United States, ²The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, MD, United States, ³Michael E.DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX, United States, ⁴Chronic Effects of Neurotrauma Consortium, Richmond, VA, United States

In this study we evaluate the effects of spatial normalization of individual fractional anisotropy (FA) maps to widely used population templates for analysis and its introduction of variability, creating spurious differences in the measured FA values.

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