The aim of this work is to compare FA and AFD as integrity parameter of white matter between groups of different ages to evaluate which areas of the white matter are affected in its fiber composition in the healthy aging process, and to evaluate if it happens in a global or specific manner. The results show that the largest decreases in FA and AFD occur in the brain of the elderly (over 60 years) due to more advanced axonal degeneration. AFD seems to show complementary information for understanding the white matter integrity alterations throughout the lifespan.
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