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Abstract #1587

Diffusion exchange spectroscopic imaging of the spinal cord

Dan Benjamini1, Michal E Komlosh1,2, and Peter J Basser1

1Section on Quantitative Imaging and Tissue Sciences, National Institutes of Health, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States

Diffusion exchange spectroscopy (DEXSY) is successfully used in conjunction with imaging on the spinal cord, and with excellent prospects for preclinical and clinical applications. DESXY is a model-free approach to measure water migration between and among distinct microenvironments. The time dependency of water migration from the intra- and extracellular microdomains indicates that different regions within gray or white matter exhibit different exchange kinetics, and points to the importance of the spatial scale of this heterogeneity.

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