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Abstract #1600

Intra- and inter-subject variability of diffusivity by DTI and DKI: An small animal study on 7T

Hung-Yu Fu1, Wei-Cheng Lee1, Sheng-Min Huang1, Shin-Lei Peng2, Kung-Chu Ho3, and Fu-Nien Wang1

1Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 3Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

Diffusivity can be acquired by both DTI and DKI model on the same set of images. To investigate intra- and inter-subject variability of DKI and DTI derived diffusivities, five Sprague- Dawley rats were scanned on a 7T small animal scanner. In intra-subject variability test, lower coefficients of variation are found on DKI derived parameters. In inter-subject analysis, higher values were estimated by DKI in mean diffusivity, axial diffusivity, and radial diffusivity. The CNR between white matter and gray matter of these parameters are also better with DKI. However, the CNR of FA is higher with DTI than with DKI

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