Abstract #1600

Intra- and inter-subject variability of diffusivity by DTI and DKI: An small animal study on 7T

Hung-Yu Fu¹, Wei-Cheng Lee¹, Sheng-Min Huang¹, Shin-Lei Peng², Kung-Chu Ho³, and Fu-Nien Wang¹

¹Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan, ²Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ³Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

Diffusivity can be acquired by both DTI and DKI model on the same set of images. To investigate intra- and inter-subject variability of DKI and DTI derived diffusivities, five Sprague- Dawley rats were scanned on a 7T small animal scanner. In intra-subject variability test, lower coefficients of variation are found on DKI derived parameters. In inter-subject analysis, higher values were estimated by DKI in mean diffusivity, axial diffusivity, and radial diffusivity. The CNR between white matter and gray matter of these parameters are also better with DKI. However, the CNR of FA is higher with DTI than with DKI

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