Information about intracortical fibers and connectivity can potentially be obtained using diffusion weighted imaging (DWI). However, in vivo intracortical DWI requires extraordinarily high spatial resolution. We demonstrate in vivo DWI imaging in the human occipital cortex with an isotropic resolution of 800 μm enabled by a high-performance 300 mT/m gradient system and flexible high-sensitivity RF receive coil optimized for cortical imaging. Robust detection of intracortical features was achieved in a reasonable scanning time. The described setup opens the exciting possibility to study intracortical connectomics in humans in vivo.
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