Abstract #1618

In-vivo line-scan diffusion MR at 250 micron inline resolution within human cerebral cortex at 7T

Mukund Balasubramanian^1,2, Robert V. Mulkern^1,2, Jeffrey J. Neil^1,3, Stephan E. Maier^1,4,5, and Jonathan R. Polimeni^1,6,7

¹Harvard Medical School, Boston, MA, United States, ²Department of Radiology, Boston Children's Hospital, Boston, MA, United States, ³Department of Neurology, Boston Children's Hospital, Boston, MA, United States, ⁴Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁵Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁶Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁷Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

We used the line-scan technique to measure in-vivo diffusion at 7T within human primary somatosensory cortex (S1) and primary motor cortex (M1), achieving voxel sizes as low as 0.25 mm in the radial direction (i.e., orthogonal to the cortical surface). Our results are consistent with recent reports of predominantly tangential diffusion in S1 and, to a lesser extent, radial diffusion in M1; however, the smaller voxel sizes used in our study alleviate concerns regarding partial-volume effects and, perhaps more importantly, enable the study of fine-scale variations in diffusion structure across cortical layers.

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