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Abstract #1619

Evaluation of Monopolar Diffusion-Prepared TSE for Diffusion Imaging

Jialu Zhang1,2,3, Xiufeng Li3, Kamil Ugurbil3, Anna Wang Roe1,2, Xiaotong Zhang1,2,4, and Dingxin Wang3

1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China, 2College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, 4Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China

EPI-based diffusion imaging methods are dominantly used, but suffer from susceptibility associated distortion and signal loss, making it challenging to achieve high-quality high-resolution diffusion imaging results. To overcome these challenges, we implemented monopolar diffusion preparation module for TSE sequence (DP-TSE) and evaluated the performance in comparison to readout segmented multi-shot echo planner (RESOLVE) sequence for diffusion weighted imaging (DWI). Our study results suggest that Diffusion-Prepared TSE is a promising alternative for distortion-free, high-resolution diffusion imaging with superior diffusion SNR.

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