Meeting Banner
Abstract #1629

In vivo DTI-based free-water elimination with T2-weighting

Ezequiel Farrher1, Richard Buschbeck1, Chang-Hoon Choi1, Li-Wei Kuo2,3, Seong-Dae Yun1, Farida Grinberg1,4, and N. Jon Shah1,4,5,6,7

1Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, 2Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 3Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 4Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 5JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany, 6Institute of Neuroscience and Medicine 11, Forschungszentrum Jülich, Jülich, Germany, 7Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

Free-water elimination allows one to reduce the bias in DTI metrics induced by partial-volume effects. Unfortunately the fitting problem for this model is ill-conditioned. However, it has been recently demonstrated that the introduction of a second dimension determined by the echo-time, leads to a well-conditioned fitting problem. In this work we investigate the experimental design and data analysis pipeline of such experiments in vivo.

This abstract and the presentation materials are available to members only; a login is required.

Join Here