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Abstract #1639

An integrated model-based framework for the correction of signal pile-up and translational offsets in prostate diffusion MRI

Muhammad Usman1, Lebina Kakkar2, Karin Shmueli3, Simon Arridge1, and David Atkinson2

1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Centre for Medical Imaging, Division of Medicine, University College London, London, United Kingdom, London, United Kingdom, 3Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, London, United Kingdom

Prostate diffusion EPI scans suffer from geometric distortions, signal pile-up and signal drop-out due to differences in susceptibility values at interface between prostate and rectal-air. In this work, an integrated model based framework is proposed that can correct for signal pile-up in regions of severe distortions and can compensate for any translational offsets that may exist between different scans. In-vivo validation of the proposed method is done in patients.

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