Abstract #1639

An integrated model-based framework for the correction of signal pile-up and translational offsets in prostate diffusion MRI

Muhammad Usman¹, Lebina Kakkar², Karin Shmueli³, Simon Arridge¹, and David Atkinson²

¹Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ²Centre for Medical Imaging, Division of Medicine, University College London, London, United Kingdom, London, United Kingdom, ³Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, London, United Kingdom

Prostate diffusion EPI scans suffer from geometric distortions, signal pile-up and signal drop-out due to differences in susceptibility values at interface between prostate and rectal-air. In this work, an integrated model based framework is proposed that can correct for signal pile-up in regions of severe distortions and can compensate for any translational offsets that may exist between different scans. In-vivo validation of the proposed method is done in patients.

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