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Abstract #1656

Diffusion MRI as a descriptive imaging marker of the pathogenesis of treatment-resistant depression.

Julie Coloigner1, Jean-Marie Batail1,2,3, Isabelle Corouge1, Jean-Christophe Ferré1,4, Dominique Drapier2,3, and Christian Barillot1

1Univ Rennes, INRIA, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, 2Academic Psychiatry Department, Centre Hospitalier Guillaume Régnier, Rennes, France, 3EA 4712 Behavior and Basal Ganglia, CHU Rennes, University of Rennes 1, Rennes, France, 4Department of Neuroradiology, University Hospital of Rennes, Rennes, France

Despite the extensive therapy options available for depression, treatment-resistant depression (TRD) occurs in 20-30% of depressed patients. . Consequently, identification of neural changes in TRD could support to better understand the mechanism of resistance and to improve the treatment of individual depressed patients. We aimed to investigate the white-matter microstructure in a sample of depressed patients in which response to treatment was subsequently evaluated 6 months after. Our findings suggest the abnormalities of the white-matter integrity in multiple white matter tracts, such as anterior limb of internal capsule and genu of corpus may play a role in the pathogenesis of treatment-resistant depression.

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