Abstract #1656

Diffusion MRI as a descriptive imaging marker of the pathogenesis of treatment-resistant depression.

Julie Coloigner¹, Jean-Marie Batail^1,2,3, Isabelle Corouge¹, Jean-Christophe Ferré^1,4, Dominique Drapier^2,3, and Christian Barillot¹

¹Univ Rennes, INRIA, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, ²Academic Psychiatry Department, Centre Hospitalier Guillaume Régnier, Rennes, France, ³EA 4712 Behavior and Basal Ganglia, CHU Rennes, University of Rennes 1, Rennes, France, ⁴Department of Neuroradiology, University Hospital of Rennes, Rennes, France

Despite the extensive therapy options available for depression, treatment-resistant depression (TRD) occurs in 20-30% of depressed patients. . Consequently, identification of neural changes in TRD could support to better understand the mechanism of resistance and to improve the treatment of individual depressed patients. We aimed to investigate the white-matter microstructure in a sample of depressed patients in which response to treatment was subsequently evaluated 6 months after. Our findings suggest the abnormalities of the white-matter integrity in multiple white matter tracts, such as anterior limb of internal capsule and genu of corpus may play a role in the pathogenesis of treatment-resistant depression.

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