Abstract #1659

Functional organisation of the hyperdirect pathway by in vivo structural connectivity imaging in healthy humans at 3T

Gizem Temiz^1,2, Chantal François¹, Carine Karachi^1,3, Sonia Pujol⁴, Eric Bardinet^1,2, and Sophie Bernadette Sébille^1,2

¹Brain and Spine Institute, CNRS UMR 7225 - INSERM U 1127 - UPMC-P6 UMR S 1127, Paris, France, ²Center of NeuroImaging Research - CENIR, Paris, France, ³AP-HP, Hôpital de la Pitié-Salpêtrière, Department of Neurosurgery, Paris, France, ⁴Surgical Planning Laboratory, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States

The goal of this study is to investigate the anatomo-functional organization of the hyperdirect pathway between the subthalamic nucleus (STN) and the cortex in humans. We identified motor, limbic and associative areas of the whole cortex. We used DWI from 30 healthy subjects and probabilistic tractography between the STN and 39 cortical areas. The motor part of the hyperdirect pathway was found predominant compare to the limbic and above all the associative parts.

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