Abstract #1658

Altered white matter tracts in schizophrenia with persistent negative symptoms

Jing-Ying Huang^1,2, Chih-Min Liu^3,4, Tzung-Jeng Hwang^3,4, Yung-Chin Hsu¹, Hai-Gwo Hwu^3,4, and Wen-Yih Isaac Tseng^1,4,5,6

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Radiology, Wei Gong Memorial Hospital, Miaoli, Taiwan, ³Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, ⁴Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, ⁵Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁶Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

This article aimed to investigate the alteration of white matter tracts in schizophrenia with persistent negative symptoms (PNS) in an attempt to identify white matter tracts that are characteristic of PNS. We performed diffusion spectrum imaging (DSI) and whole brain tract-based automatic analysis (TBAA) to compare the tract integrity among healthy controls, PNS and non-PNS groups. Our results showed that the right uncinate fasciculus and bilateral thalamic radiations of the ventral lateral prefrontal cortex are tract correlates of PNS.

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