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Abstract #1661

Optic radiation tractography in pediatric brain tumor and epilepsy surgery: a test-retest reliability assessment of the tractography method

Joseph Yuan-Mou Yang1,2,3, Richard Beare1,4, Michelle Hao Wu5, Sarah M. Barton1,6,7, Charles B. Malpas1,8, Vicki Anderson6,8,9,10, Wirginia J Maixner2,3, and Marc L Seal1,6

1Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 2Neuroscience Research, Murdoch Children's Research Institute, Melbourne, Australia, 3Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 4Medicine, Monash University, Melbourne, Australia, 5Medical Imaging, The Royal Children's Hospital, Melbourne, Australia, 6Paediatrics, University of Melbourne, Melbourne, Australia, 7Neurology, the Royal Children's Hospital, Melbourne, Australia, 8Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia, 9Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia, 10Psychology, the Royal Children's Hospital, Melbourne, Australia

Existing optic radiation (OR) tractography methods lack pediatric and surgical focus. We proposed a clinically feasible tractography framework and examined its test-retest reliability using both the preoperative and intraoperative MRI from eight pediatric epilepsy and brain tumor patients. Good to excellent intra- and inter-rater reproducibility was demonstrated in the assessments of all diffusion and morphological track metrics. The reconstructions closely resembled classic anatomy. All OR images were used to assist surgical planning and resection. Postoperatively, no patient had new visual field deficits. Our tractography method generates reproducible OR images that can be safely implemented in routine, non-emergency pediatric neurosurgical settings.

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