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Abstract #1662

Impaired executive and visual network integrity in patients with Parkinson’s disease and psychosis: A structural connectome based study

Abhishek Lenka1, Apurva Shah2, Jitender Saini3, Pramod Kumar Pal1, and Madhura Ingalhalikar2

1Neurology, NIMHANS, Bengaluru, India, 2Department of Electronics, Symbiosis Institute of Technology, Symbiosis International University, Pune, India, 3Radiology, NIMHANS, Bengaluru, India

Psychosis manifested as formed visual hallucinations is one of the debilitating non-motor symptoms of Parkinson’s disease (PD), the patho-physiology of which remains unclear. To gain insights into the neural correlates of psychosis in PD this study analyzed the structural connectomic sub-networks of visual, executive and memory circuits between patients with PD and psychosis (PD-P), PD without psychosis (PD-NP) and controls (HC). When PD-P and HCs were compared, a global connectivity deficit was observed in the visual and executive circuits and multiple connections within the visual network demonstrated significantly lower connectivity in PD-P. Such changes were not observed in PD-NP vs. HCs.

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