Psychosis manifested as formed visual hallucinations is one of the debilitating non-motor symptoms of Parkinson’s disease (PD), the patho-physiology of which remains unclear. To gain insights into the neural correlates of psychosis in PD this study analyzed the structural connectomic sub-networks of visual, executive and memory circuits between patients with PD and psychosis (PD-P), PD without psychosis (PD-NP) and controls (HC). When PD-P and HCs were compared, a global connectivity deficit was observed in the visual and executive circuits and multiple connections within the visual network demonstrated significantly lower connectivity in PD-P. Such changes were not observed in PD-NP vs. HCs.
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