Abstract #1670

DW-MRI in assessment of 3D Cell Culture

Jui-Heng Lin¹, Hao-Chun Peng¹, Shao-Chieh Lin², Yi-Jui Liu², Ruey-Hwang Chou³, Ke-Sin Yan³, Tan-Wei Liao³, Chia-Wei Lin⁴, Chao-Chun Lin⁴, Wei-Ching Lin ⁴, and Wu-Chung Shen⁴

¹Master's Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichung, Taiwan, ²Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ³Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ⁴Department of Radiology, China Medical University Hospital, Taichung, Taiwan

In extracellular and intracellular space, the Brownian motion of water is restricted by organelles, cellmembranes, and extracellular fibers. DWI is sensitivity to microscopic motion, which is due to Brownian motion of water molecules. In this study, 3D cell culture with hydrogels ECM was used to investigate whether DWI may provide information on these microenvironmental parameters and the microenvironment-associated metastatic propensity of tumors. Our results demonstrated DW-MRI may provide the potential biomarkers on the change of microenvironment in the application of 3D cell culture experiment.

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