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Abstract #1672

Novel Multi-band accelerated, Reference-less, Multifaceted Icosahedral and Multishell Diffusion MRI Protocol for human whole brain clinical applications

Khader M Hasan1, Refaat E Gabr1, John A Lincoln2, and Ponnada A Narayana1

1Diagnostic and Interventional Radiology, UThealth, Houston, TX, United States, 2Neurology, UThealth, Houston, TX, United States

We describe a comprehensive multishell and multifaceted icosahedral diffusion MRI protocol that enables whole brain coverage in less than 10 minutes using multiband (MB) technology at 3 T. We show the protocol utility in providing estimates of blood fraction, extent of CSF-contamination, diffusion tensor and kurtosis derived measures including fractional, axonal water fraction and extracellular tortuosity. The diffusion gradient encoding is based the Icosa6 and Icosa15 sets forming the Icosa21 for additional quality assurance. In this report we describe the protocol, show feasibility and utility for mapping a host of useful quantitative measures in the same session without repeated scans.

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