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Abstract #1766

High-Resolution Radial Diffusivity Images Provide Insights of Fetal Brain Development

Akiko Uematsu1,2,3, Keigo Hikishima4, Junichi Hata1,3, and Hideyuki Okano2,3

1Central Institute for Experimental Animals, Kanagawa, Japan, 2RIKEN Brain Science Institute, Saitama, Japan, 3Keio University School of Medicine, Tokyo, Japan, 4Okinawa Institute of Science and Technology, Okinawa, Japan

Investigating prenatal neural development provide depth knowledge of brain ontogeny. DTI-derived radial diffusivity (RD) imaging has advantage to provide information of microstructural tissue organization information without damaging the tissues. In this study, we investigate the changes of the radial diffusivity (RD) values during fetal development in non-human primate. The RD image contrast was enough to clearly depict the emergence of each brain regions as well as major white matter bundles during prenatal period. In addition, its whole brain intensity distribution histogram provided the information of critical period for the growth of myelination.

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