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Abstract #1767

Preeclampsia related to delayed development of white matter and cortical infolding.

Ting Liu1, Miaomiao Wang1, Chao Jin1, Xianjun Li1, and Jian Yang1

1Department of Diagnostic Radiology, the first Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

Offspring born from preeclampsia exhibit deficits in cognitive impairment. But the pathogenesis is not clear. We assessed brain maturation and white matter development in neonatal period using total maturation score and tract-based spatial statistics. TMS showed the scores of TMS, B and C scores were lower in preeclampsia group. TBSS results displayed FA values decreased, while AD and RD values increased on anterior & posterior limb of internal capsule, external capsule, splenium of corpus callosum, optic radiation and centrum semiovale in preeclampsia group. The results indicated preeclampsia is associated with delayed development of white matter and cortical infolding.

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