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Abstract #1768

Is cortical microstructure related to folding during development? A longitudinal MRI study in preterms

Alexandra Hertz1, Antonietta Pepe2, Julien Lefevre2, Marie Zomeno1, Francois Leroy1, Jessica Lebenberg1,3, Linda de Vries4, Floris Groenendaal4, David Germanaud5, Manon Benders4, and Jessica Dubois1

1INSERM, Gif-sur-Yvette, France, 2Aix-Marseille University, CNRS, Marseille, France, 3CEA, Gif-sur-Yvette, France, 4Wilhelmina Children's Hospital, University Medical Center, Utrecht, Netherlands, 5APHP, INSERM, Paris, France

The human brain cortex develops dramatically during the preterm period, in terms of both morphology, intra-cortical maturation and dendritic arborization. Here we aimed to investigate whether different stages of microstructural maturation are observed in cortical regions that fold successively. We studied preterm infants longitudinally at around 30 and 40 weeks of post-menstrual age, and combined measures from diffusion tensor imaging (DTI) and spectral analysis of gyrification (SPANGY). We highlighted that proxies of primary folds have an advanced microstructural maturation early on, and that the progression until term age is more intense in proxies of secundary folds than in gyri.

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