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Abstract #1775

High resolution neonatal brain relaxometry in 10 minutes – A preliminary proof of concept

Rui Pedro A. G. Teixeira1, Tomoki Arichi1, Johannes Steinweg1, Katy Vecchiato1, Sophie Arulkumaran1, Shaihan J. Malik1, Mary A. Rutherford1, Joseph V. Hajnal1, and Serena J. Counsell1

1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Quantitative MRI promises to allow objective and reproducible tissue metrics which are of special interest in newborn brain maturation characterization. However, such methods require acquisition times above 20 minutes which hinders their clinical applicability. With an increasing trend towards examination without sedation during natural sleep, subject motion is an important issue for neonatal applications. With this in mind, this work builds on the previously described Joint System Relaxometry framework and presents a neonatal specific protocol which allows 1.25mm isotropic 3D maps of Proton Density, T1 and T2 relaxation times in a total of 10minutes examination time.

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