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Abstract #1777

Optimization of phase-contrast MRI for cerebral blood flow quantification in neonates

Peiying Liu1, Charlamaine Parkinson1, Dengrong Jiang1, Jill B De Vis1, Li Pan2, Himanshu Bhat2, Andrea Poretti1, Frances Northington1, Aylin Tekes1, Thierry Huisman1, and W Christopher Golden1

1Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Siemens Healthineers, Baltimore, MD, United States

Knowledge of CBF in neonates may provide valuable information in many pathological conditions. When applied to very young children, CBF mapping using arterial-spin-labeling (ASL) MRI suffers from low signal-to-noise ratio and poor quantification, whereas phase-contrast (PC) MRI may provide reliable estimation of global CBF. This study aimed to optimize the PC-MRI protocol for future applications in neonates. By comparing the cardiac-gated and non-gated implementations, we found non-gated PC-MRI could provide accurate CBF measurement with shorter scan time. We also found lower imaging resolution would over-estimate CBF, and therefore recommend the use of 0.3mm resolution with 6 averages in neonates.

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