Abstract #1777

Optimization of phase-contrast MRI for cerebral blood flow quantification in neonates

Peiying Liu¹, Charlamaine Parkinson¹, Dengrong Jiang¹, Jill B De Vis¹, Li Pan², Himanshu Bhat², Andrea Poretti¹, Frances Northington¹, Aylin Tekes¹, Thierry Huisman¹, and W Christopher Golden¹

¹Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Siemens Healthineers, Baltimore, MD, United States

Knowledge of CBF in neonates may provide valuable information in many pathological conditions. When applied to very young children, CBF mapping using arterial-spin-labeling (ASL) MRI suffers from low signal-to-noise ratio and poor quantification, whereas phase-contrast (PC) MRI may provide reliable estimation of global CBF. This study aimed to optimize the PC-MRI protocol for future applications in neonates. By comparing the cardiac-gated and non-gated implementations, we found non-gated PC-MRI could provide accurate CBF measurement with shorter scan time. We also found lower imaging resolution would over-estimate CBF, and therefore recommend the use of 0.3mm resolution with 6 averages in neonates.

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