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Abstract #1787

Motor connectivity of the midbrain in healthy children defined using connectivity based parcellation

Sonja Soskic1, Hannah Cooper2, Alexandra Bonthrone3, and Chris A. Clark1

1Developmental Imaging and Biophysics Section, UCL GOS Institute of Child Health, University College London, London, United Kingdom, 2UCL Ear Institute, University College London, London, United Kingdom, 3Cognitive Neuroscience and Neuropsychiatry Section, UCL GOS Institute of Child Health, University College London, London, United Kingdom

Delineation of midbrain regions connected with the motor cortex may be useful in evaluating disruptions of motor pathways in paediatric patients. We used the established winner-takes-it-all method to parcellate the midbrain according to cortical connectivity in healthy children aged 6-12 years. The percentage of ipsilateral midbrain occupied by motor parcels was negatively associated with age on the right side only, producing an association between age and interhemispheric asymmetry. Our findings indicate that age and interhemispheric differences need to be taken into account if this method is to be utilised for quantitative comparisons of midbrain-motor connectivity in children.

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