Abstract #1788

Assessing white matter development in peri-pubertal children using longitudinal fixel-based analysis

Sila Genc^1,2, Robert E Smith³, Charles B Malpas², Vicki A Anderson^4,5, Jan M Nicholson⁶, Daryl Efron⁵, Timothy J Silk^1,2, and Marc L Seal^1,2

¹Department of Paediatrics, The University of Melbourne, Parkville, Australia, ²Developmental Imaging, Murdoch Childrens Research Institute, Parkville, Australia, ³The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia, ⁴Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Australia, ⁵The Royal Children's Hospital, Parkville, Australia, ⁶Judith Lumley Centre, La Trobe University, Melbourne, Australia

Recent evidence suggests that the pubertal period corresponds with changes to white matter microstructure above and beyond age-related development. This study uses a longitudinal fixel-based analysis to investigate which regions of the brain correspond to changes in white matter fibre density and cross-section during pubertal development. We show that, over a 16-month follow-up period, increases in fibre density and cross-section are predominantly in the posterior white matter. These results add to evidence that white matter develops in a posterior-anterior fashion, and signifies the dynamic nature of brain development during puberty.

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