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Abstract #1788

Assessing white matter development in peri-pubertal children using longitudinal fixel-based analysis

Sila Genc1,2, Robert E Smith3, Charles B Malpas2, Vicki A Anderson4,5, Jan M Nicholson6, Daryl Efron5, Timothy J Silk1,2, and Marc L Seal1,2

1Department of Paediatrics, The University of Melbourne, Parkville, Australia, 2Developmental Imaging, Murdoch Childrens Research Institute, Parkville, Australia, 3The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia, 4Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Australia, 5The Royal Children's Hospital, Parkville, Australia, 6Judith Lumley Centre, La Trobe University, Melbourne, Australia

Recent evidence suggests that the pubertal period corresponds with changes to white matter microstructure above and beyond age-related development. This study uses a longitudinal fixel-based analysis to investigate which regions of the brain correspond to changes in white matter fibre density and cross-section during pubertal development. We show that, over a 16-month follow-up period, increases in fibre density and cross-section are predominantly in the posterior white matter. These results add to evidence that white matter develops in a posterior-anterior fashion, and signifies the dynamic nature of brain development during puberty.

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