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Abstract #1789

Longitudinal myelin development in children born very preterm compared with typically developing peers

Deanne Thompson1,2,3,4, Joseph Yang2,5,6, Jian Chen2, Claire Kelly1,2, Bonnie Alexander1,2, Lillian Matthews7, Katherine Lee1,3,8, Rod Hunt1,3,9, Jeanie Cheong1,10,11, Megan Spencer-Smith1,12, Marc Seal2,3, Jeffrey Neil7, Terrie Inder1,7, Lex Doyle1,3,10,11, and Peter Anderson1,3,12

1Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, 2Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 3Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 4Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 5Neuroscience Research, Murdoch Children's Research Institute, Melbourne, Australia, 6Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 7Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 8Clinical Epidemiology & Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia, 9Neonatal Medicine, The Royal Children's Hospital, Melbourne, Australia, 10Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, 11The Royal Women's Hospital, Melbourne, Australia, 12Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia

Myelin development over time in preterm children remains unclear. This study compared T1/T2 myelin maps for 81 very preterm (VP) and 29 full-term children between 7 and 13 years of age. On average, VP children had higher T1/T2 ratios than full-term children in most white matter tracts and deep gray matter structures at both time points. This may reflect compensation or developmental catch-up. T1/T2 ratios increased from childhood to adolescence in both VP and full-term children, shedding light on typical and atypical myelin maturation.

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